Emerging insights in the management of hemoglobin E beta thalassemia


Journal article


N. Olivieri, Vivekanandan Thayalsuthan, A. O’Donnell, A. Premawardhena, Christopher Rigobon, G. Muraca, C. Fisher, D. Weatherall
Annals of the New York Academy of Sciences, 2010

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APA   Click to copy
Olivieri, N., Thayalsuthan, V., O’Donnell, A., Premawardhena, A., Rigobon, C., Muraca, G., … Weatherall, D. (2010). Emerging insights in the management of hemoglobin E beta thalassemia. Annals of the New York Academy of Sciences.


Chicago/Turabian   Click to copy
Olivieri, N., Vivekanandan Thayalsuthan, A. O’Donnell, A. Premawardhena, Christopher Rigobon, G. Muraca, C. Fisher, and D. Weatherall. “Emerging Insights in the Management of Hemoglobin E Beta Thalassemia.” Annals of the New York Academy of Sciences (2010).


MLA   Click to copy
Olivieri, N., et al. “Emerging Insights in the Management of Hemoglobin E Beta Thalassemia.” Annals of the New York Academy of Sciences, 2010.


BibTeX   Click to copy

@article{n2010a,
  title = {Emerging insights in the management of hemoglobin E beta thalassemia},
  year = {2010},
  journal = {Annals of the New York Academy of Sciences},
  author = {Olivieri, N. and Thayalsuthan, Vivekanandan and O’Donnell, A. and Premawardhena, A. and Rigobon, Christopher and Muraca, G. and Fisher, C. and Weatherall, D.}
}

Abstract

Globally, hemoglobin (Hb) E β thalassemia accounts for approximately half the severe forms of β thalassemia. Because of its wide clinical diversity and the ability of patients with this condition to adapt unusually well to low hemoglobin levels, the management of Hb E β thalassemia, particularly the decision to instigate regular blood transfusion, is particularly difficult. Here, we present a summary of our work in patients with this condition, which attempts to define clinical, adaptive, and genetic factors of possible value in determining the early management of this condition.