Giulia M. Muraca, PhD - Maternal, Fetal and Infant outcomes Associated

Journal article

A. Doumouras, Giulia M. Muraca, Elizabeth K. Darling, Emma K. O’Callaghan, Francis Nguyen, V. Boudreau, M. Anvari
Annals of Surgery, 2024

Semantic Scholar DOI

Cite

APA Click to copy
Doumouras, A., Muraca, G. M., Darling, E. K., O’Callaghan, E. K., Nguyen, F., Boudreau, V., & Anvari, M. (2024). Maternal, Fetal and Infant outcomes Associated with Bariatric Surgery. Annals of Surgery.

Chicago/Turabian Click to copy
Doumouras, A., Giulia M. Muraca, Elizabeth K. Darling, Emma K. O’Callaghan, Francis Nguyen, V. Boudreau, and M. Anvari. “Maternal, Fetal and Infant Outcomes Associated with Bariatric Surgery.” Annals of Surgery (2024).

MLA Click to copy
Doumouras, A., et al. “Maternal, Fetal and Infant Outcomes Associated with Bariatric Surgery.” Annals of Surgery, 2024.

BibTeX Click to copy

@article{a2024a,
  title = {Maternal, Fetal and Infant outcomes Associated with Bariatric Surgery},
  year = {2024},
  journal = {Annals of Surgery},
  author = {Doumouras, A. and Muraca, Giulia M. and Darling, Elizabeth K. and O’Callaghan, Emma K. and Nguyen, Francis and Boudreau, V. and Anvari, M.}
}

Abstract

The purpose of this study was to determine the association between bariatric surgery and maternal, fetal and infant outcomes.

Obesity during pregnancy is a risk factor for adverse pregnancy outcomes. Bariatric surgery is the most effective weight loss treatment but the impact of bariatric surgery on pregnancy outcomes remains poorly characterised.

This was a population-based, matched cohort study of prospective databases in Ontario, Canada. Patients with obesity who received bariatric surgery from 2010 to 2016 and subsequently became pregnant matched on multiple factors to non-surgical pregnant patients with obesity. The primary outcomes of interest were the incidence included of gestational diabetes, preeclampsia/HELLP syndrome, small for gestational age (SGA), large for gestational age (LGA), and a composite of severe fetal/infant morbidity/mortality. Multivariable regression evaluated outcomes.

680 patients who underwent bariatric surgery and later became pregnant were matched to 2002 pregnant patients with obesity. Gestational diabetes occurred in 8.7% of the surgery group and 18.8% of the non-surgical group (adjusted OR (aOR) 0.29, 95%CI 0.21-0.40, P<0.001). A lower incidence of preeclampsia/HELLP was observed post-surgery (aOR 0.20, 95%CI 0.13-0.31, P<0.001). Bariatric surgery impacted SGA (aOR 2.74, 95%CI 2.04–3.70, P<0.001) and LGA (aOR 0.25, 95%CI 0.18-0.36, P<0.001). There were no observed associations between bariatric surgery and any adverse fetal or infant outcomes. A lower composite severe fetal/infant morbidity/mortality was observed post-surgery (aOR 0.73, 95%CI 0.54-0.97, P<0.05).

Pregnancy after bariatric surgery appears safe and was associated with a reduced risk of several obesity related adverse pregnancy outcomes.